Mental Health  |  OST Drug Issues Pathway - Metabolism and Excretion

Mental Health

OST Drug Issues Pathway - Metabolism and Excretion

Buprenorphine is primarily metabolized via the cytochrome P450 pathway in the liver. Care should be taken when co-prescribing medications which induce this pathway (carbamazepine, phenytoin, phenobarbital, rifampin, reverse-transcriptase inhibitors) or inhibit it (azole antifungals, macrolide antibiotics, protease inhibitors).Buprenorphine metabolites are primarily (70%) eliminated in the faeces by biliary excretion, with the remainder excreted in the urine. Naloxone is eliminated via the urine.

Last updated : Friday, August 21, 2015
Next review date : Saturday, August 20,2016

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