Buprenorphine is primarily metabolized via the cytochrome P450 pathway in the liver. Care should be taken when co-prescribing medications which induce this pathway (carbamazepine, phenytoin, phenobarbital, rifampin, reverse-transcriptase inhibitors) or inhibit it (azole antifungals, macrolide antibiotics, protease inhibitors).Buprenorphine metabolites are primarily (70%) eliminated in the faeces by biliary excretion, with the remainder excreted in the urine. Naloxone is eliminated via the urine.
Disclaimer: This site is intended to be flexible and frequently updated. While every effort has been made to ensure accuracy, all information should be verified.