Mental Health  |  OST Drug Issues Pathway - Buprenorphine/Naloxone Interactions




Mental Health

OST Drug Issues Pathway - Buprenorphine/Naloxone Interactions

Consideration should be given to the potential interactions with Buprenorphine/Naloxone before the following medications are prescribed:

  • CNS depressants, narcotics.
  • General anaesthetics.
  • MAOIs.
  • Mitochondrial toxins (aspirin, isoniazid, valproate, amiodarone, antiviral nucleoside analogues).
  • CYP3A4 inhibitors (protease inhibitors, azole antifungals, calcium channel blockers, macrolides).
  • CYP3A4 inducers (phenobarbitone, carbamazepine, phenytoin, rifampicin).

*See Section 4.4 Drug Interactions page 34 and Appendix 5 Drug Interaction page 103 of " New Zealand Practice Guidelines for Opioid Substitution Treatment 2014"



Last updated : Thursday, January 09, 2020
Next review date : Friday, January 08,2021


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