Mental Health  |  OST Drug Issues Pathway - Suboxone Interactions

Mental Health

OST Drug Issues Pathway - Suboxone Interactions

Consideration should be given to the potential interactions with Suboxone before the following medications are prescribed:

  • CNS depressants, narcotics.
  • General anesthetics.
  • MAOIs.
  • Mitochondrial toxins (aspirin, isoniazid, valproate, amiodarone, antiviral nucleoside analogues).
  • CYP3A4 inhibitors (protease inhibitors, azole antifungals, calcium channel blockers, macrolides).
  • CYP3A4 inducers (phenobarbitone, carbamazepine, phenytoin, rifampicin).

*See Section 4.4 Drug Interactions page 34 and Appendix 5 Drug Interaction page 103 of New Zealand Practice Guidelines for Opioid Substitution Treatment 2014"

Last updated : Friday, August 21, 2015
Next review date : Saturday, August 20,2016

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