Signs and symptoms of opioid withdrawal:
The onset of methadone or suboxone withdrawal starts at 24 to 48 hours after the last dose. The duration of methadone or suboxone withdrawal is up to 21 days. Psychological and neurological (including pain receptors) adjustments can last up to six months. Research indicates withdrawal symptoms from suboxone are less than from methadone.
Signs and symptoms of opioid intoxication/overdose:
In cases of overdose ensure that the airway is clear and perform emergency cardiopulmonary resuscitation as necessary.
Transfer to hospital as soon as possible where treatment with an infusion of naloxone can be commenced.
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